WG4

Integration of (epi)lipidomics with lipid signalling and mechanisms of action

Objectives

Integration of the current knowledge on lipid signalling and modes of action with the focus on developing the expertise hub on lipid signalling mechanisms, mainly related to the role of native and modified lipids as well as their protein interactions in a variety of model systems, including cell culture and animal models. It will be based on analytical, molecular, cellular and biophysical approaches to tackle the mechanisms of action of lipid species.

Expected outcomes

  1. Collection and exchange of the model systems (cell lines, animal models; material and knowledge exchange) used by the network as a joint resource available to the EpiLipidNET participants
  2. Collection and exchange of the SOPs and expertise of analytical, biochemical and biophysical methods for the detection and functional assessment of lipid-protein interactions, covalent and noncovalent
  3. Development of a database on protein-lipid interactions and associated functional effects
  4. Integration of available data on lipid signalling and metabolic pathways
  5. Integration and curation of pathways summarizing lipid related signaling

WG4 Leader

Florian Gruber
Medical University of Vienna, Austria

WG4 Vice-leader

Egon Willighagen
Maastricht University, Netherlands

CA19105 – Pan-European Network in Lipidomics and EpiLipidomics

CSO Approval Date: 24 March 2020
Start Date: 13 October 2020
End Date: 12 October 2024
EpiLipidNET aims to build and maintain a multidisciplinary pan-European network of researchers, clinicians and enterprises working in the field of lipidomics and epilipidomics to boost a hub of research excellence, advanced knowledge and technology transfer, to promote high level of training for young researchers and facilitate clinical translation.