WG3

Clinical significance and applications of (epi)lipidomics

Objectives

To establish a roadmap for clinical translation of MS-based lipidomics by bringing together participants working in clinical diagnostic and laboratory medicine, clinicians, researchers involved in method development and validation, biostatisticians and commercial enterprises developing lipid standards and diagnostic kits. The main focus of WG3 is a network – and community – wide assessment of the putative implementation strategies of lipid derived markers in clinical workflows considering analytical and clinical performance, clinical and cost effectiveness, and impact.

Expected outcomes

  1. Standardization of preanalytical workflows for sample collection, biobanking, storage and management in clinical environment for biofluids and tissue samples
  2. Assessment of the inter-individual variability factors in clinical lipidomics including age, gender, ethnicity, diet and lifestyle, medication history and disease conditions
  3. Development of a workflow for the establishment of reference values for selected lipids
  4. Definition, assessment and promotion of reference materials to increase comparability of large scale lipidomic studies
  5. Development, optimization, implementation and exchange of biostatistics tools and machine learning algorithm for lipid biomarker discovery and validation in large clinical cohorts

WG3 Leader

Matej Orešič
University of Turku (Finland), and associate professor at Örebro University (Sweden)

WG3 Vice-leader

Margrét Thorsteinsdóttir
University of Iceland, Reykjavík, Iceland

CA19105 – Pan-European Network in Lipidomics and EpiLipidomics

CSO Approval Date: 24 March 2020
Start Date: 13 October 2020
End Date: 12 October 2024
EpiLipidNET aims to build and maintain a multidisciplinary pan-European network of researchers, clinicians and enterprises working in the field of lipidomics and epilipidomics to boost a hub of research excellence, advanced knowledge and technology transfer, to promote high level of training for young researchers and facilitate clinical translation.