Dissemination & Outreach

One of EpilipidNET’s main goals is to contribute to the wider public understanding of the importance of different kinds of lipids and their measurement in everyday life. To achieve this goal, EpilipidNET develops and disseminates content explaining the project’s scope of action and results.

Videos about EpiLipidNET

Welcome to EpiLipidNET!

Educational Suite

Lipids (fats & oils) are biomolecules that are very important for the proper functioning of our cells, tissues, and organs. Lipids play a crucial role in the function of our immune system, cardiovascular system, nervous system, memory, and the health of our skin. On the other hand, excessive consumption of calorie-rich foods, combined with a sedentary lifestyle, can result in unhealthy weight gain, leading to negative consequences for our health. Our body can synthesize many of its lipids, but some essential lipids must be obtained through our diet and are important for health. However, we must keep in mind that highly processed commercial food is often rich in trans-fats that can have some negative health effects if consumed excessively. Thus, no individual food is absolutely unhealthy and lipids themselves are not inherently bad. Balance and moderation are essential. Lipodrome and Know Your Fats! aim to illustrate these concepts through fun but educational board game for all the family.

For info, reach out to: epilipidnet@ua.pt

NEWS ABOUT EpiLipidNET educational suite:

The board game Lipodrome was presented at the Xperimenta 2024 event by the Lipidomics Laboratory of Mass Spectrometry of the University of Aveiro (CEM-UA).  Students from a variety of backgrounds participated in this program, which allowed them to investigate the connection between dietary decisions and overall health. The game allowed players to observe how different food choices can impact our health based on the lipids they contain. 

This occasion made it possible for the EpiLipidNET COST Action and the Lipidomic Laboratory of CEM-UA to further contribute to public involvement and education in the complicated field of lipids. Additional initiatives are planned for the future, in association with Fábrica Centro Ciência Viva de Aveiro (https://www.ua.pt/pt/fabrica/saude-a-mesa-II).

Newsletters

Newsletters about activities of the members of EpiLipidNET:

  • December 2023 – We have successfully completed the third year of EpiLipidNet networking, achieving remarkable outcomes through our active collaborative network, meaningful interactions, and friendship. We are proud to celebrate the 3rd year of success that has enriched the field of lipids and lipidomics worldwide! Read more
  • July 2023 – In this edition we are bringing you news from several meetings and conferences in the first half of 2023 where EpiLipidNET members participated or organized sessions. Read more
  • December 2022 – It has been a wonderful and very fruitful 2nd year for the EpiLipidNET Action and we finally had a chance to meet face to face! Read more
  • September 2022 – Our GP2 is almost over and it has been a quite challenging, but a very good year for EpiLipidNET COST Action.  Read more
  • June 2021 – The next general Action EpiLipidNET meeting will take place (on-line via zoom; free of charge to everyone who is interested) on 23 – 24th of September! Read more

Talking about EpiLipidNET…

Podcast, press-release, and others by the members of the COST Action:

  • EpiLipidNET on the COST News! On September 2024, the COST Newsletter highlights EpiLipidNET Exploitation Meeting “Bridging lipids and society“.
  • EpiLipidNET on the COST News! We are thrilled to share the latest news about EpilipidNET on the COST News platform:

  • Medical News about EpiLipidNET participation in COST Connect: A platform for collaboration and progress in cancer research. “Amazing to see how many ideas come up if people with different background simply sit around one table and discuss possible solutions for a given problem. Diversity of expertise is the key!” Dr Maria Fedorova, vice-Chair of EpiLipidNET

  • Networking with Astromad.eu.We create synergies with researchers, projects and entities because collaborating and sharing knowledge with others is essential for scientific progress

  • Webcast presentation for the European Society for Dermatological Research by our  colleague Dr Florian Gruber (EpilipidNET WG4 leader), expert in skin lipidomics

  • A LIPID MAPS® Podcast hosted by Matthew Conroy who’s joined by Professor Laura Goracci (EpiLipidNET WG2 leader) to discuss EpiLipids. Available in Spotify, YouTube, Apple Podcasts

Publications

Publications written by the members of the COST Action:

  1. Łuczaj W, Dobrzyńska I, Wroński A, Domingues MR, Domingues P, Skrzydlewska E. Cannabidiol-Mediated Changes to the Phospholipid Profile of UVB-Irradiated Keratinocytes from Psoriatic Patients. Int J Mol Sci. 2020; 21(18):6592. doi: 10.3390/ijms21186592 (Poland-Portugal)
  2. Łuczaj W, Domingues MDR, Domingues P, Skrzydlewska E. Changes in Lipid Profile of Keratinocytes from Rat Skin Exposed to Chronic UVA or UVB Radiation and Topical Application of Cannabidiol. Antioxidants (Basel). 2020; 9(12):1178. doi: 10.3390/antiox9121178 (Poland-Portugal)
  3. Liebisch G, Fahy E, Aoki J, Dennis EA, Durand T, Ejsing CS, Fedorova M, Feussner I, Griffiths WJ, Köfeler H, Merrill AH Jr, Murphy RC, O’Donnell VB, Oskolkova O, Subramaniam S, Wakelam MJO, Spener F. Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures. J Lipid Res. 2020; 61(12):1539-1555. doi: 10.1194/jlr.S120001025 (Austria-Germany-France-United Kingdom)
  4. Köfeler HC, Eichmann TO, Ahrends R, Bowden JA, Danne-Rasche N, Dennis EA, Fedorova M, Griffiths WJ, Han X, Hartler J, Holčapek M, Jirásko R, Koelmel JP, Ejsing CS, Liebisch G, Ni Z, O’Donnell VB, Quehenberger O, Schwudke D, Shevchenko A, Wakelam MJO, Wenk MR, Wolrab D, Ekroos K. Quality control requirements for the correct annotation of lipidomics data. Nat Commun. 2021; 12(1):4771. doi: 10.1038/s41467-021-24984-y (United Kingdom-Germany)
  5. Oskolkova OV, Hodzic A, Karki P, Gesslbauer B, Ke Y, Hofer DC, Bogner-Strauss JG, Galano JM, Oger C, Birukova A, Durand T, Birukov K, Bochkov V. Oxidized phospholipids on alkyl-amide scaffold demonstrate anti-endotoxin and endothelial barrier-protective properties. Free Radic Biol Med. 2021; 174:264-271. doi: 10.1016/j.freeradbiomed.2021.07.041 (Austria-France)
  6. Viedma-Poyatos Á, González-Jiménez P, Langlois O, Company-Marín I, Spickett CM, Pérez-Sala D. Protein Lipoxidation: Basic Concepts and Emerging Roles. Antioxidants (Basel). 2021; 10(2):295. doi: 10.3390/antiox10020295 (Spain-United Kingdom)
  7. Lairón-Peris M, Routledge SJ, Linney JA, Alonso-Del-Real J, Spickett CM, Pitt AR, Guillamón JM, Barrio E, Goddard AD, Querol A. Lipid Composition Analysis Reveals Mechanisms of Ethanol Tolerance in the Model Yeast Saccharomyces cerevisiae. Appl Environ Microbiol. 2021; 87(12):e0044021. doi: 10.1128/AEM.00440-21 (Spain-United Kingdom)
  8. Gladine C, Fedorova M. The clinical translation of eicosanoids and other oxylipins, although challenging, should be actively pursued. J Mass Spectrom Adv Clin Lab. 2021; 21:27-30. doi: 10.1016/j.jmsacl.2021.08.003 (France-Germany)
  9. Atalay S, Gęgotek A, Domingues P, Skrzydlewska E. Protective effects of cannabidiol on the membrane proteins of skin keratinocytes exposed to hydrogen peroxide via participation in the proteostasis network. Redox Biol. 2021; 46:102074. doi: 10.1016/j.redox.2021.102074 (Poland-Portugal)
  10. Conde TA, Zabetakis I, Tsoupras A, Medina I, Costa M, Silva J, Neves B, Domingues P, Domingues MR. Microalgal Lipid Extracts Have Potential to Modulate the Inflammatory Response: A Critical Review. Int J Mol Sci. 2021; 22(18):9825. doi: 10.3390/ijms22189825 (Ireland-Portugal)
  11. Smolič T, Tavčar P, Horvat A, Černe U, Halužan Vasle A, Tratnjek L, Kreft ME, Scholz N, Matis M, Petan T, Zorec R, Vardjan N. Astrocytes in stress accumulate lipid droplets. Glia. 2021; 69(6):1540-1562. doi: 10.1002/glia.23978 (Germany-Slovenia)
  12. Łuczaj W, Jastrząb A, do Rosário Domingues M, Domingues P, Skrzydlewska E. Changes in Phospholipid/Ceramide Profiles and Eicosanoid Levels in the Plasma of Rats Irradiated with UV Rays and Treated Topically with Cannabidiol. Int J Mol Sci. 2021; 22(16):8700. doi: 10.3390/ijms22168700 (Poland-Portugal)
  13. Răchieriu C, Eniu DT, Moiş E, Graur F, Socaciu C, Socaciu MA, Hajjar NA. Lipidomic Signatures for Colorectal Cancer Diagnosis and Progression Using UPLC-QTOF-ESI+MS. Biomolecules. 2021; 11(3):417. doi: 10.3390/biom11030417 (Romania)
  14. Homorogan C, Nitusca D, Enatescu V, Schubart P, Moraru C, Socaciu C, Marian C. Untargeted Plasma Metabolomic Profiling in Patients with Major Depressive Disorder Using Ultra-High Performance Liquid Chromatography Coupled with Mass Spectrometry. Metabolites. 2021; 11(7):466. doi: 10.3390/metabo11070466 (Romania)
  15. Đukanović N, Obradović S, Zdravković M, Đurašević S, Stojković M, Tosti T, Jasnić N, Đorđević J, Todorović Z. Lipids and Antiplatelet Therapy: Important Considerations and Future Perspectives. Int J Mol Sci. 2021; 22(6):3180. doi: 10.3390/ijms22063180 (Serbia)
  16. Todorović Z, Đurašević S, Stojković M, Grigorov I, Pavlović S, Jasnić N, Tosti T, Macut JB, Thiemermann C, Đorđević J. Lipidomics Provides New Insight into Pathogenesis and Therapeutic Targets of the Ischemia-Reperfusion Injury. Int J Mol Sci. 2021; 22(6):2798. doi: 10.3390/ijms22062798 (Serbia-United Kingdom)
  17. Melo T, Figueiredo ARP, Costa E, Couto D, Silva J, Domingues MR, Domingues P. Ethanol Extraction of Polar Lipids from Nannochloropsis Oceanica for Food, Feed, and Biotechnology Applications Evaluated using Lipidomic Approaches. Mar Drugs. 2021; 19 (11). doi: 10.3390/md19110593 (Portugal)
  18. Maurício T, Aveiro S, Guedes S, Lopes D, Melo T, Neves BM, Domingues MR, Domingues P. Multi-Omic Profiling of Macrophages Treated with Phospholipids Containing Omega-3 and Omega-6 Fatty Acids Reveals Complex Immunomodulatory Adaptations at Protein, Lipid and Metabolic Levels. Int J Mol Sci. 2022; 23 (4). doi: 10.3390/ijms23042139 (Portugal)
  19. Neves B, Pérez-Sala D, Ferreira HB, Guerra IMS, Moreira ASP, Domingues P, Domingues MR, Melo T. Understanding the nitrolipidome: From chemistry to mass spectrometry and biological significance of modified complex lipids. Prog Lipid Res. 2022; 87:101176. doi: 10.1016/j.plipres.2022.101176 (Portugal-Spain)
  20. Conde T, Lopes D, Łuczaj W, Neves B, Pinto B, Maurício T, Domingues P, Skrzydlewska E, Domingues MR. Algal Lipids as Modulators of Skin Disease: A Critical Review. Metabolites. 2022; 12(2):96. doi: 10.3390/metabo12020096 (Poland-Portugal)
  21. Sochorová M, Vávrová K, Fedorova M, Ni Z, Slenter D, Kutmon M, Willighagen E, Letsiou S, Töröcsik D, Marchetti-Deschmann M, Zoratto S, Kremslehner C,Gruber F. Research Techniques Made Simple: Lipidomic Analysis in Skin Research. Journal of Investigative Dermatology. 2022; 142(1): 4-11.e1. doi: 10.1016/j.jid.2021.09.017 (Austria-Czech Republic-Germany-Hungary-Netherlands)
  22. Sohrabi Y, Schwarz D, Reinecke H. LDL-C augments whereas HDL-C prevents inflammatory innate immune memory. Trends in Molecular Medicine. 2022; 28(1): 1-4. doi: 10.1016/j.molmed.2021.11.003 (Czech Republic-Germany)
  23. Rey F, Greenacre M, Silva Neto GM, Bueno-Pardo J, Domingues MR, Calado R. Fatty acid ratio analysis identifies changes in competent meroplanktonic larvae sampled over different supply events. Mar Environ Res. 2022; 173:105517. doi: 10.1016/j.marenvres.2021.105517 (Portugal-Spain)
  24. McDonald JG, Ejsing CS, Kopczynski D, Holčapek M, Aoki J, Arita M, Arita M, Baker ES, Bertrand-Michel J, Bowden JA, Brügger B, Ellis SR, Fedorova M, Griffiths WJ, Han X, Hartler J, Hoffmann N, Koelmel JP, Köfeler HC, Mitchell TW, O’Donnell VB, Saigusa D, Schwudke D, Shevchenko A, Ulmer CZ, Wenk MR, Witting M, Wolrab D, Xia Y, Ahrends R, Liebisch G, Ekroos K. Introducing the Lipidomics Minimal Reporting Checklist. Nat Metab. 2022; 4(9):1086-1088. doi: 10.1038/s42255-022-00628-3 (United Kingdom-Germany)
  25. Káňovičová P, Čermáková P, Kubalová D, Bábelová L, Veselá P, Valachovič M, Zahumenský J, Horváth A, Malínský J, Balážová M. Blocking phosphatidylglycerol degradation in yeast defective in cardiolipin remodeling results in a new model of the Barth syndrome cellular phenotype. J Biol Chem. 2022; 298(1):101462. doi: 10.1016/j.jbc.2021.101462 (Slovakia-Czech Republik)
  26. Žarković N, Orehovec B, Baršić B, Tarle M, Kmet M, Lukšić I, Tatzber F, Wonisch W, Skrzydlewska E, Łuczaj W. Lipidomics Revealed Plasma Phospholipid Profile Differences between Deceased and Recovered COVID-19 Patients. Biomolecules. 2022; 12(10):1488. doi: 10.3390/biom12101488 (Austria-Croatia-Poland)
  27. Žarković N, Łuczaj W, Jarocka-Karpowicz I, Orehovec B, Baršić B, Tarle M, Kmet M, Lukšić I, Biernacki M, Skrzydlewska E. Diversified Effects of COVID-19 as a Consequence of the Differential Metabolism of Phospholipids and Lipid Peroxidation Evaluated in the Plasma of Survivors and Deceased Patients upon Admission to the Hospital. Int J Mol Sci. 2022; 23(19):11810. doi: 10.3390/ijms231911810 (Croatia-Poland)
  28. Criscuolo A, Nepachalovich P, Garcia-Del Rio DF, Lange M, Ni Z, Baroni M, Cruciani G, Goracci L, Blüher M, Fedorova M. Analytical and computational workflow for in-depth analysis of oxidized complex lipids in blood plasma. Nat Commun. 2022; 13(1):6547. doi: 10.1038/s41467-022-33225-9 (Germany-Italy)
  29. Ferreira HB, Barros C, Melo T, Paiva A, Domingues MR. Looking in Depth at Oxidized Cholesteryl Esters by LC-MS/MS: Reporting Specific Fragmentation Fingerprints and Isomer Discrimination. J Am Soc Mass Spectrom. 2022; 33(5):793-802. doi: 10.1021/jasms.1c00370 (Portugal)
  30. Ferreira HB, Guerra IMS, Melo T, Rocha H, Moreira ASP, Paiva A, Domingues MR. Dried blood spots in clinical lipidomics: optimization and recent findings. Anal Bioanal Chem. 2022;414(24):7085-7101. doi: 10.1007/s00216-022-04221-1 (Portugal)
  31. Eniu DT, Chiorean AR, Socaciu AI, Staicu A, Rachieriu C, Goidescu I, Buiga R, Eniu D, Socaciu C, Chira R. Blood and urine biomarkers in invasive ductal breast cancer: Mass spectrometry applied to identify metabolic alterations. Journal of Molecular Structure. 2022; 1247, doi: 10.1016/j.molstruc.2021.131369 (Romania)
  32. Burghelea D, Moisoiu T, Ivan C, Elec A, Munteanu A, Iancu ȘD, Truta A, Kacso TP, Antal O, Socaciu C, Elec FI, Kacso IM. The Use of Machine Learning Algorithms and the Mass Spectrometry Lipidomic Profile of Serum for the Evaluation of Tacrolimus Exposure and Toxicity in Kidney Transplant Recipients. Biomedicines. 2022; 10(5):1157. doi: 10.3390/biomedicines10051157 (Romania)
  33. Nenu I, Stefanescu H, Procopet B, Sparchez Z, Minciuna I, Mocan T, Leucuta D, Morar C, Grigorescu M, Filip GA, Socaciu C. Navigating through the Lipid Metabolism Maze: Diagnosis and Prognosis Metabolites of Hepatocellular Carcinoma versus Compensated Cirrhosis. J Clin Med. 2022; 11(5):1292. doi: 10.3390/jcm11051292 (Romania)
  34. Fischer P, Pandrea S, Grigoras C, Stefanescu H, Farcau O, Tefas C, Socaciu C, Procopet B, Ionescu D. Blood Metabolomic Signatures to Identify Bacterial Infection in Patients with Decompensated Cirrhosis. J Gastrointestin Liver Dis. 2022; 31(1):40-47. doi: 10.15403/jgld-4034 (Romania)
  35. Socaciu C, Dulf F, Socaci S, Ranga F, Bunea A, Fetea F, Pintea A. Phytochemical Profile of Eight Categories of Functional Edible Oils: A Metabolomic Approach Based on Chromatography Coupled with Mass Spectrometry. Applied Sciences. 2022; 12(4):1933. doi: 10.3390/app12041933 (Romania)
  36. Ismaiel A, Spinu M, Socaciu C, Budisan L, Leucuta DC, Popa SL, Chis BA, Berindan-Neagoe I, Olinic DM, Dumitrascu DL. Metabolic biomarkers related to cardiac dysfunction in metabolic-dysfunction-associated fatty liver disease: a cross-sectional analysis. Nutr Diabetes. 2022; 12(1):4. doi: 10.1038/s41387-022-00182-7 (Romania)
  37. Rey F, Melo T, Lopes D, Couto D, Marques F, Domingues MR. Applications of lipidomics in marine organisms: progress, challenges and future perspectives. Mol Omics. 2022; 18(5):357-386. doi: 10.1039/d2mo00012a (Portugal)
  38. Alves E, Rey F, Melo T, Barros MP, Domingues P, Domingues R. Bioprospecting Bioactive Polar Lipids from Olive (Olea europaea cv. Galega vulgar) Fruit Seeds: LC-HR-MS/MS Fingerprinting and Sub-Geographic Comparison. Foods. 2022; 11(7):951. doi: 10.3390/foods11070951 (Portugal)
  39. Couto D, Conde TA, Melo T, Neves B, Costa M, Cunha P, Guerra I, Correia N, Silva J, Pereira H, Varela J, Silva J, Domingues R, Domingues P. Effects of Outdoor and Indoor Cultivation on the Polar Lipid Composition and Antioxidant Activity of Nannochloropsis Oceanica and Nannochloropsis Limnetica: A Lipidomics Perspective. Algal Research. 2022; 64. doi: 10.1016/j.algal.2022.102718. (Portugal)
  40. Couto D, Melo T, Conde TA, Moreira ASP, Ferreira P, Costa M, Silva J, Domingues R, Domingues P. Food grade extraction of Chlorella vulgaris polar lipids: A comparative lipidomic study. Food Chem. 2022; 375:131685. doi: 10.1016/j.foodchem.2021.131685. (Portugal)
  41. Bartolomeu M, Vieira C, Dias M, Conde T, Couto D, Lopes D, Neves B, Melo T, Rey F, Alves E, Silva J, Abreu H, Almeida A, Domingues MR. Bioprospecting antibiotic properties in photodynamic therapy of lipids from Codium tomemtosum and Chlorella vulgaris. Biochimie. 2022; 203:32-39. doi: 10.1016/j.biochi.2022.09.012 (Portugal)
  42. Guerra IMS, Ferreira HB, Melo T, Rocha H, Moreira S, Diogo L, Domingues MR, Moreira ASP. Mitochondrial Fatty Acid β-Oxidation Disorders: From Disease to Lipidomic Studies-A Critical Review. Int J Mol Sci. 2022; 23(22):13933. doi: 10.3390/ijms232213933 (Portugal)
  43. Gaspar L, Ricardo F, Melo T, Domingues P, Domingues MR, Calado R, Rey F. Lipidomics of common octopus’ (Octopus vulgaris) arm muscle using untargeted high-resolution liquid chromatography-mass spectrometry. Journal of Food Composition and Analysis. 2023; 115, 104871. doi: 10.1016/j.jfca.2022.104871 (Portugal)
  44. Sarmento, M.J., Llorente, A., Petan, T., Khnykin, D., Popa, I., Perkovic, M. N., Konjevod, M., Jaganjac, M. The expanding organelle lipidomes: current knowledge and challenges. Cell. Mol. Life Sci. 2023; 80, 237. doi: 10.1007/s00018-023-04889-3 (Portugal-Norway-Slovenia-France-Croatia)
  45. Ferreira HB, Melo T, Rocha H, Paiva A, Domingues P, Domingues MR. Lipid profile variability in children at different ages measured in dried blood spots. Mol Omics. 2023; 19(3):229-237. doi: 10.1039/d2mo00206j (Portugal)
  46. Kovács D, Camera E, Póliska S, Cavallo A, Maiellaro M, Dull K, Gruber F, Zouboulis C C, Szegedi A, Törócsik D.  Linoleic Acid Induced Changes in SZ95 Sebocytes—Comparison with Palmitic Acid and Arachidonic Acid. Nutrients. 2023; 15, 3315. doi: 10.3390/nu15153315 (Hungary-Italy-Austria-Germany)
  47. Tietel Z, Hammann S, Meckelmann SW, Ziv C, Pauling JK, Wölk M, Würf V, Alves E, Neves B, Domingues MR. An overview of food lipids toward food lipidomics. Compr. Rev. Food Sci. Food Saf. 2023; 1–53. doi:10.1111/1541-4337.13225 (Israel-Germany-Portugal)
  48. Bonciarelli S, Neves B, Domingues P, Melo T, Goracci L, Domingues MR. Analysis of Phosphatidylinositol Modifications by Reactive Nitrogen Species Using LC-MS: Coming to Grips with Their Nitroxidative Susceptibility. J. Am. Soc. Mass Spectrom. 2023; 34 (7): 1372-1382. doi:10.1021/jasms.3c00057 (Italy-Portugal)
  49. Jovičić EJ, Janež AP, Eichmann TO, Koren Š, Brglez V, Jordan PM, Gerstmeier J, Lainšček D, Golob-Urbanc A, Jerala R, Lambeau G, Werz O, Zimmermann R, Petan T. Lipid droplets control mitogenic lipid mediator production in human cancer cells. Mol Metab. 2023; 76:101791. doi: 10.1016/j.molmet.2023.101791 (Slovenia-Austria-Germany-France)
  50. Ferreira HB, Melo T, Guerra IMS, Moreira ASP, Laranjeira P, Paiva A, Goracci L, Bonciarelli S, Domingues P, Domingues MR. Whole Blood and Plasma-Based Lipid Profiling Reveals Distinctive Metabolic Changes in Systemic Lupus Erythematosus and Systemic Sclerosis. J Proteome Res. 2023; 22(9):2995-3008. doi: 10.1021/acs.jproteome.3c00321 (Portugal-Italy)
  51. Raclariu-Manolică AC, Socaciu C. In Search of Authenticity Biomarkers in Food Supplements Containing Sea Buckthorn: A Metabolomics Approach. Foods. 2023; 12(24):4493. doi: 10.3390/foods12244493 (Romania)
  52. Jusović M, Starič P, Jarc Jovičić E, Petan T. The Combined Inhibition of Autophagy and Diacylglycerol Acyltransferase-Mediated Lipid Droplet Biogenesis Induces Cancer Cell Death during Acute Amino Acid Starvation. Cancers (Basel). 2023; 15(19):4857. doi: 10.3390/cancers15194857 (Slovenia)
  53. Hoboth P, Sztacho M, Quaas A, Akgül B, Hozák P. Quantitative super-resolution microscopy reveals the differences in the nanoscale distribution of nuclear phosphatidylinositol 4,5-bisphosphate in human healthy skin and skin warts. Front Cell Dev Biol. 2023; 11:1217637. doi: 10.3389/fcell.2023.1217637 (Czechia-Germany)
  54. Julve J, Genua I, Quifer-Rada P, Yanes Ó, Barranco-Altirriba M, Hernández M, Junza A, Capellades J, Granado-Casas M, Alonso N, Castelblanco E, Mauricio D. Circulating metabolomic and lipidomic changes in subjects with new-onset type 1 diabetes after optimization of glycemic control. Diabetes Res Clin Pract. 2023; 197:110578. doi: 10.1016/j.diabres.2023.110578 (Spain)
  55. González-Jiménez P, Duarte S, Martínez AE, Navarro-Carrasco E, Lalioti V, Pajares MA, Pérez-Sala D. Vimentin single cysteine residue acts as a tunable sensor for network organization and as a key for actin remodeling in response to oxidants and electrophiles. Redox Biol. 2023; 64:102756. doi: 10.1016/j.redox.2023.102756 (Spain)
  56. Abraúl M, Alves A, Hilário S, Melo T, Conde T, Domingues MR, Rey F. Evaluation of Lipid Extracts from the Marine Fungi Emericellopsis cladophorae and Zalerion maritima as a Source of Anti-Inflammatory, Antioxidant and Antibacterial Compounds. Mar Drugs. 2023; 21(4):199. doi: 10.3390/md21040199 (Portugal)
  57. Parchem K, Baranowska M, Kościelak A, Kłosowska-Chomiczewska I, Domingues MR, Macierzanka A, Bartoszek A. Effect of oxidation and in vitro intestinal hydrolysis on phospholipid toxicity towards HT29 cell line serving as a model of human intestinal epithelium. Food Res Int. 2023; 163:112227. doi: 10.1016/j.foodres.2022.112227 (Poland-Portugal)
  58. Łuczaj W, Gęgotek A, Conde T, Domingues MR, Domingues P, Skrzydlewska E. Lipidomic assessment of the impact of Nannochloropsis oceanica microalga lipid extract on human skin keratinocytes exposed to chronic UVB radiation. Sci Rep. 2023; 13(1):22302. doi: 10.1038/s41598-023-49827-2 (Poland-Portugal)
  59. Rey F, Cartaxana P, Cruz S, Melo T, Domingues MR. Revealing the polar lipidome, pigment profiles, and antioxidant activity of the giant unicellular green alga, Acetabularia acetabulum. J Phycol. 2023; 59(5):1025-1040. doi: 10.1111/jpy.13367 (Portugal)
  60. Ni Z, Wölk M, Jukes G, Mendivelso Espinosa K, Ahrends R, Aimo L, Alvarez-Jarreta J, Andrews S, Andrews R, Bridge A, Clair GC, Conroy MJ, Fahy E, Gaud C, Goracci L, Hartler J, Hoffmann N, Kopczyinki D, Korf A, Lopez-Clavijo AF, Malik A, Ackerman JM, Molenaar MR, O’Donovan C, Pluskal T, Shevchenko A, Slenter D, Siuzdak G, Kutmon M, Tsugawa H, Willighagen EL, Xia J, O’Donnell VB, Fedorova M. Guiding the choice of informatics software and tools for lipidomics research applications. Nat Methods. 2023; 20(2):193-204. doi: 10.1038/s41592-022-01710-0 (Germany-United Kingdom-Austria-Switzerland-USA-Italy-Czech Republic-Netherlands-Japan-Canada)
  61. Conde T, Aveiro S, Melo T, Santos T, Neves B, Domingues P, Varela J, Pereira H, Domingues MR. Cross-stress lipid response of Tetraselmis striata CTP4 to temperature and salinity variation. Algal Research. 2023; 74, 103218. doi: 10.1016/j.algal.2023.103218 (Portugal)
  62. Silva KM, Wölk M, Nepachalovich P, Iturrospe E, Covaci A, Nuijs ALN, Fedorova M. Investigating the Potential of Drift Tube Ion Mobility for the Analysis of Oxidized Lipids. Anal Chem. 2023; 95 (36), 13566-13574. doi: 10.1021/acs.analchem.3c02213 (Belgium-Germany)
  63. Danielli M, Perne L, Jarc Jovičić E, Petan T. Lipid droplets and polyunsaturated fatty acid trafficking: Balancing life and death. Front Cell Dev Biol. 2023 Jan 27;11:1104725. doi: 10.3389/fcell.2023.1104725. Erratum in: Front Cell Dev Biol. 2023; 11:1175493. doi: 10.3389/fcell.2023.1175493 (Slovenia)
  64. Stasiewicz A, Conde T, Gęgotek A, Domingues MR, Domingues P, Skrzydlewska E. Prevention of UVB Induced Metabolic Changes in Epidermal Cells by Lipid Extract from Microalgae Nannochloropsis oceanica. Int J Mol Sci. 2023; 24(14):11302. doi: 10.3390/ijms241411302 (Poland-Portugal)
  65. Vondrackova M, Kopczynski D, Hoffmann N, Kuda O. LORA, Lipid Over-Representation Analysis Based on Structural Information. Anal Chem. 2023; 95 (34), 12600-12604. doi: 10.1021/acs.analchem.3c02039 (Czechia-Austria-Germany)
  66. Monteiro FL, Góis A, Direito I, Melo T, Neves B, Alves MI, Batista I, Domingues MDR, Helguero LA. Inhibiting SETD7 methyl-transferase activity impairs differentiation, lipid metabolism and lactogenesis in mammary epithelial cells. FEBS Lett. 2023; 597(21):2656-2671. doi: 10.1002/1873-3468.14737 (Portugal)
  67. Bayona-Hernandez A, Guerra S, Jiménez-Ramirez IA, Sztacho M, Hozak P, Rodriguez-Zapata LC, Pereira-Santana A, Castaño E. LIPRNAseq: a method to discover lipid interacting RNAs by sequencing. Mol Biol Rep. 2023; 50(8):6619-6626. doi: 10.1007/s11033-023-08548-5 (Mexico-Czech Republic)
  68. Marques F, Lopes D, Conde T, Melo T, Silva J, Abreu MH, Domingues P, Domingues MR. Lipidomic Characterization and Antioxidant Activity of Macro- and Microalgae Blend. Life (Basel). 2023; 13(1):231. doi: 10.3390/life13010231 (Portugal)
  69. Damiani T, Bonciarelli S, Thallinger GG, Koehler N, Krettler CA, Salihoğlu AK, Korf A, Pauling JK, Pluskal T, Ni Z, Goracci L. Software and Computational Tools for LC-MS-Based Epilipidomics: Challenges and Solutions. Anal Chem. 2023; 95(1):287-303. doi: 10.1021/acs.analchem.2c04406 (Czech Republic-Italy-Austria-Germany-Turkey)
  70. Biernacki M, Conde T, Stasiewicz A, Surażyński A, Domingues MR, Domingues P, Skrzydlewska E. Restorative Effect of Microalgae Nannochloropsis oceanica Lipid Extract on Phospholipid Metabolism in Keratinocytes Exposed to UVB Radiation. Int J Mol Sci. 2023; 24(18):14323. doi: 10.3390/ijms241814323 (Poland-Portugal)
  71. Couto D, Conde TA, Melo T, Neves B, Costa M, Silva J, Domingues R, Domingues P. The chemodiversity of polar lipidomes of microalgae from different taxa. Algal Research. 2023; 70, 103006. doi: 10.1016/j.algal.2023.103006 (Portugal)
  72. Rey F, Cartaxana P, Aveiro S, Greenacre M, Melo T, Domingues P, Domingues MR, Cruz S. Light modulates the lipidome of the photosynthetic sea slug Elysia timida. Biochim Biophys Acta Mol Cell Biol Lipids. 2023; 1868(2):159249. doi: 10.1016/j.bbalip.2022.159249 (Portugal-Spain)
  73. Balaban C, Sztacho M, Antiga L, Miladinović A, Harata M, Hozák P. PIP2-Effector Protein MPRIP Regulates RNA Polymerase II Condensation and Transcription. Biomolecules. 2023; 13(3):426. doi: 10.3390/biom13030426 (Czech Republic-Japan)
  74. Lopes D, Rey F, Melo T, Moreira ASP, Marques F, Abreu MH, Domingues P, Domingues MR. Mapping the Polar Lipidome of Macroalgae using LC‐MS‐Based Approaches for Add‐Value Applications. Eur J Lipid Sci Technol. 2023; 125(6). doi: 10.1002/ejlt.202300005 (Portugal)
  75. Schmid R, Heuckeroth S, Korf A, Smirnov A, Myers O, Dyrlund TS, Bushuiev R, Murray KJ, Hoffmann N, Lu M, Sarvepalli A, Zhang Z, Fleischauer M, Dührkop K, Wesner M, Hoogstra SJ, Rudt E, Mokshyna O, Brungs C, Ponomarov K, Mutabdžija L, Damiani T, Pudney CJ, Earll M, Helmer PO, Fallon TR, Schulze T, Rivas-Ubach A, Bilbao A, Richter H, Nothias LF, Wang M, Orešič M, Weng JK, Böcker S, Jeibmann A, Hayen H, Karst U, Dorrestein PC, Petras D, Du X, Pluskal T. Integrative analysis of multimodal mass spectrometry data in MZmine 3. Nat Biotechnol. 2023; 41(4):447-449. doi: 10.1038/s41587-023-01690-2 (USA-Germany-Czech Republic-Denmark-China-Canada-Australia-United Kingdom-Spain-Switzerland-Sweden)
  76. Jardim T, Domingues MRM, Alves E. An overview on lipids in nuts and oily fruits: oil content, lipid composition, health effects, lipidomic fingerprinting and new biotechnological applications of their by-products. Crit Rev Food Sci Nutr. 2023; 13:1-29. doi: 10.1080/10408398.2023.2208666 (Portugal)
  77. Ramos-Molina B, Rossell J, Pérez-Montes de Oca A , Pardina E, Genua I, Rojo-López MI, Julián MT, Alonso N, Julve J, Mauricio D. Therapeutic implications for sphingolipid metabolism in metabolic dysfunction-associated steatohepatitis. Front Endocrinol. 2024; 15. doi: 10.3389/fendo.2024.1400961 (Spain)
  78. Jouhet J, Alves E, Boutté Y, Darnet S, Domergue F, Durand T, Fischer P, Fouillen L, Grube M, Joubès J, Kalnenieks U, Kargul JM, Khozin-Goldberg I, Leblanc C, Letsiou S, Lupette J, Markov GV, Medina I, Melo T, Mojzeš P, Momchilova S, Mongrand S, Moreira ASP, Neves BB, Oger C, Rey F, Santaeufemia S, Schaller H, Schleyer G, Tietel Z, Zammit G, Ziv C, Domingues R. Plant and algal lipidomes: Analysis, composition, and their societal significance. Prog Lipid Res. 2024; 96:101290. doi: 10.1016/j.plipres.2024.101290 (France-Portugal-Latvia-Poland-Israel-Greece-Spain-Czech Republic-Bulgaria-Germany-Malta)
  79. Guerra IMS, Ferreira HB, Maurício T, Pinho M, Diogo L, Moreira S, Goracci L, Bonciarelli S, Melo T, Domingues P, Domingues MR, Moreira ASP. Plasma lipidomics analysis reveals altered profile of triglycerides and phospholipids in children with Medium-Chain Acyl-CoA dehydrogenase deficiency. J Inherit Metab Dis. 2024; 47(4):731-745. doi: 10.1002/jimd.12718 (Portugal-Italy)
  80. Hodzic A, Gesslbauer B, Bochkov V, Oskolkova OV. Cooperative induction of CXCL chemokines by inflammatory cytokines and oxidized phospholipids. Immunology. 2024. doi: 10.1111/imm.13773 (Austria)
  81. Escudeiro-Lopes S, Filimonenko VV, Jarolimová L, Hozák P. Lamin A/C and PI(4,5)P2-A Novel Complex in the Cell Nucleus. Cells. 2024; 13(5):399. doi: 10.3390/cells13050399 (Czech Republic)
  82. Neves BB, Pinto S, Pais R, Batista J, Domingues MR, Melo T. Looking into the lipid profile of avocado and byproducts: Using lipidomics to explore value-added compounds. Compr Rev Food Sci Food Saf. 2024; 23(3):e13351. doi: 10.1111/1541-4337.13351 (Portugal)
  83. Ferreira HB, Domingues MR. Oxidized phospholipid-protein adducts: The future targets of interest. Arch Biochem Biophys. 2024; 754:109956. doi: 10.1016/j.abb.2024.109956 (Portugal)
  84. Monteiro JP, Domingues MR, Calado R. Marine Animal Co-Products-How Improving Their Use as Rich Sources of Health-Promoting Lipids Can Foster Sustainability. Mar Drugs. 2024; 22(2):73. doi: 10.3390/md22020073 (Portugal)
  85. Parchem K, Letsiou S, Petan T, Oskolkova O, Medina I, Kuda O, O’Donnell VB, Nicolaou A, Fedorova M, Bochkov V, Gladine C. Oxylipin profiling for clinical research: Current status and future perspectives. Prog Lipid Res. 2024; 95:101276. doi: 10.1016/j.plipres.2024.101276 (Czech Republic-Greece-Slovenia-Austria-Spain-United Kingdom-Germany-France)
  86. Fernandes T, Melo T, Conde T, Neves B, Domingues P, Resende R, Pereira CF, Moreira PI, Domingues MR. Mapping the lipidome in mitochondria-associated membranes (MAMs) in an in vitro model of Alzheimer’s disease. J Neurochem. 2024; 168(7):1237-1253. doi: 10.1111/jnc.16072 (Portugal)
  87. Stasiewicz A, Conde T, Domingues MDR, Domingues P, Biernacki M, Skrzydlewska E. Comparison of the Regenerative Metabolic Efficiency of Lipid Extracts from Microalgae Nannochloropsis oceanica and Chlorococcum amblystomatis on Fibroblasts. Antioxidants (Basel). 2024; 13(3):276. doi: 10.3390/antiox13030276 (Poland-Portugal)
  88. Varandas PAMM, Belinha R, Cobb AJA, Prates Ramalho JP, Segundo MA, Loura LMS, Silva EMP. Flow-based bioconjugation of coumarin phosphatidylethanolamine probes: Optimised synthesis and membrane molecular dynamics studies. Biochim Biophys Acta Biomembr. 2024; 1866(7):184335. doi: 10.1016/j.bbamem.2024.184335 (Portugal-United Kingdom)
  89. Darwish A, Pammer M, Gallyas F Jr, Vígh L, Balogi Z, Juhász K. Emerging Lipid Targets in Glioblastoma. Cancers (Basel). 2024; 16(2):397. doi: 10.3390/cancers16020397 (Hungary)
  90. Kose B, Erkanlı S, Koçak A, Guzel C, Luider T, Dias IHK, Baykal AT. Exploring oxysterols and protein carbonylation in cervicovaginal secretions as biomarkers for cervical cancer development. Advances in Redox Research. 2024; 13:100111. doi: 10.1016/j.arres.2024.100111 (Turkey-Netherlands-United Kingdom)
  91. Barranco-Altirriba M, Alonso N, Weber RJM, Lloyd GR, Hernandez M, Yanes O, Capellades J, Jankevics A, Winder C, Falguera M, Franch-Nadal J, Dunn WB, Perera-Lluna A, Castelblanco E, Mauricio D. Lipidome characterisation and sex-specific differences in type 1 and type 2 diabetes mellitus. Cardiovasc Diabetol. 2024; 23(1):109. doi: 10.1186/s12933-024-02202-5 (Spain-United Kingdom-Netherlands)
  92. Mouskeftara T, Deda O, Liapikos T, Panteris E, Karagiannidis E, Papazoglou AS, Gika H. Lipidomic-Based Algorithms Can Enhance Prediction of Obstructive Coronary Artery Disease. J Proteome Res. 2024; 23(8):3598-3611. doi: 10.1021/acs.jproteome.4c00249 (Greece)
  93. Hoboth P, Sztacho M, Hozák P. Nuclear patterns of phosphatidylinositol 4,5- and 3,4-bisphosphate revealed by super-resolution microscopy differ between the consecutive stages of RNA polymerase II transcription. FEBS J. 2024. doi: 10.1111/febs.17136  (Czech Republic)
  94. Marques F, Pinho M, Guerra I, Conde TA, Silva J, Cardoso M, Martins M, Abreu H, Cerqueira M, Domingues MR. Unlocking functional lipid ingredients from algae by food-grade biosolvents and ultrasound-assisted extraction for nutritional applications. LWT 200. 2024; 116136. doi: 10.1016/j.lwt.2024.116136 (Portugal)
  95. Fernández Requena B, Nadeem S, Reddy VP, Naidoo V, Glasgow JN, Steyn AJC, Barbas C, Gonzalez-Riano C. LiLA: lipid lung-based ATLAS built through a comprehensive workflow designed for an accurate lipid annotation. Commun Biol. 2024; 7(1):45. doi: 10.1038/s42003-023-05680-7 (Spain-USA-South Africa)
  96. Santos M, Melo T, Maurício T, Ferreira H, Domingues P, Domingues R. The non-enzymatic oxidation of phosphatidylethanolamine and phosphatidylserine and their intriguing roles in inflammation dynamics and diseases. FEBS Lett. 2024. doi: 10.1002/1873-3468.14992 (Portugal)
  97. Witting M, Malik A, Leach A, Bridge A, Aimo L, Conroy MJ, O’Donnell VB, Hoffmann N, Kopczynski D, Giacomoni F, Paulhe N, Gassiot AC, Poupin N, Jourdan F, Bertrand-Michel J. Challenges and perspectives for naming lipids in the context of lipidomics. Metabolomics. 2024; 20(1):15. doi: 10.1007/s11306-023-02075-x (Germany-United Kingdom-Austria-France-Singapore)
  98. Torta F, Hoffmann N, Burla B, Alecu I, Arita M, Bamba T, Bennett SAL, Bertrand-Michel J, Brügger B, Cala MP, Camacho-Muñoz D, Checa A, Chen M, Chocholoušková M, Cinel M, Chu-Van E, Colsch B, Coman C, Connell L, Sousa BC, Dickens AM, Fedorova M, Eiríksson FF, Gallart-Ayala H, Ghorasaini M, Giera M, Guan XL, Haid M, Hankemeier T, Harms A, Höring M, Holčapek M, Hornemann T, Hu C, Hülsmeier AJ, Huynh K, Jones CM, Ivanisevic J, Izumi Y, Köfeler HC, Lam SM, Lange M, Lee JC, Liebisch G, Lippa K, Lopez-Clavijo AF, Manzi M, Martinefski MR, Math RGH, Mayor S, Meikle PJ, Monge ME, Moon MH, Muralidharan S, Nicolaou A, Nguyen-Tran T, O’Donnell VB, Orešič M, Ramanathan A, Riols F, Saigusa D, Schock TB, Schwartz-Zimmermann H, Shui G, Singh M, Takahashi M, Thorsteinsdóttir M, Tomiyasu N, Tournadre A, Tsugawa H, Tyrrell VJ, van der Gugten G, Wakelam MO, Wheelock CE, Wolrab D, Xu G, Xu T, Bowden JA, Ekroos K, Ahrends R, Wenk MR. Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards. Nat Commun. 2024; 15(1):8562. doi: 10.1038/s41467-024-52087-x (Singapore-Germany-Austria-Canada-Japan-France-Colombia-United Kingdom-Sweden-Czech Republic-Australia-USA-Finland-Iceland-Switzerland- The Netherlands-China-South Korea-Argentina-India-Qatar)
CA19105 – Pan-European Network in Lipidomics and EpiLipidomics

CSO Approval Date: 24 March 2020
Start Date: 13 October 2020
End Date: 12 October 2024
EpiLipidNET aims to build and maintain a multidisciplinary pan-European network of researchers, clinicians and enterprises working in the field of lipidomics and epilipidomics to boost a hub of research excellence, advanced knowledge and technology transfer, to promote high level of training for young researchers and facilitate clinical translation.